Welcome to Kuroda Lab Ultimate goal of our study is understanding of mechanism of signal transduction networks that regulate various cellular functions including cell-fate determination, synaptic plasticity and insulin actions at systems level. In these biological processes, the same input stimulation elicits distinct outcomes depending temporal patterns of input, and we are interested in quantitative mechanisms of the encoding/decoding systems via signaling networks that underlie these processing. We use both experimental and computational approaches. Thus, we are trying to understand cellular processes in terms of Systems Biology.

12.04.09 Our recent study on signaling sensitivity has been highlighted on the University webpage 12.04.05 "Seminars" updated (by Dr. Hisao Moriya; April 24(Tues.), Faculty of Science Bldg.3, 3F, room 310) 12.04.04 "Members" updated. 12.03.13 "Publications" updated. "Latent process genes for cell differentiation are common decoders of neurite extension length" has been accepted by Journal of Cell Science. 12.03.13 "Publications" updated. "Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signalling" has been accepted by Nature Communications. (Press Release) 12.01.05 We co-organize a joint symposium by JST/BBSRC(UK) entitled "Molecular Imaging and Systems Biology" on Jan. 30 and 31, 2012 at Yayoi Auditorium in Univ. of Tokyo. (Details) 12.01.05 "Seminars" updated (by Dr. Timothy C. Elston and Dr. Andre Levchenko; January 27(Fri.), Faculty of Science Bldg.3, 4F, room 412) 11.11.29 "Seminars" updated (by Dr. Shunsuke Teraguchi; December 01(Thu.), Faculty of Science Bldg.3, 4F, room 412) 11.09.29 Working papers by Sophie Andrews and Davis Yunlong Liu. are uploaded. 11.08.30 The UTRIP2011 has successfully been ended. Here the comments from Sophie Andrews and Davis Yunlong Liu. 11.07.08 UTRIP students （Sophie,Davis）are joining us. 11.02.16 "Publications" updated. "Analysis of Development of Direction Selectivity in Retinotectum by a Neural Circuit Model with Spike Timing-Dependent Plasticity." has been accepted by The Journal of Neuroscience. 11.02.14 UTRIP2011 (University of Tokyo Research Internship Program) We encourage to apply UTRIP2011, the summer school for international undergraduate students. We will provide you a chance to experience cutting edge of advanced systems biology of cellular signaling. Any background (not only biology, but also physics, mathematics, chemistry and computer science) is welcome. We have financial support , including travel expense to Japan, accommodation and others. For information those who consider to apply our lab, see the working paper and comments by the 2010 participant, Yang Yu. 10.07.27 "Decoupling of Receptor and Downstream Signals in Akt Pathway by Its Low-pass Filter Characteristics" has been accepted by Science Signaling. (Press Release) 10.04.02 "Publications" updated. "A Quantitative Image Cytometry Technique for Time Series or Population Analyses of Signaling Networks" has been accepted by PLoS ONE. 10.02.09 "Publications" updated. "Timing-Dependent Actions of NGF Required for Cell Differentiation" has been accepted by PLoS ONE. 09.10.19 We visited Michael Stumpf's lab at Imperial College London (Nov. 13 - Nov. 15, 2009). 08.07.16 The review of Ras and Rap1 as a differentiator and integrator is here. 08.02.22 "Publications" updated.A novel allosteric kinetics of NMDAR in STDP has been accepted by J. Neuroscience.